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Handfoot skin reaction caused by multi-kinase inhibitors TKIs have been associated with various cutaneous AEs, including nonspecific morbilliform rash, mucositis, alopecia, changes in skin color, splinter hemorrhages, edema, ulcers and delayed healing, palmar-plantar rash, and scrotal or vulvar erythema-eczema

The efficiency of TMAO production varies depending on the precursor compounds

For your reference: For your reference: For your reference: 10, 24 Aliabadi, Elham, et al

Activity and safety of enobosarm, a novel, oral, selective androgen receptor modulator, in androgen receptor-positive, oestrogen receptor-positive, and HER2-negative advanced breast cancer (Study G200802): a randomised, open-label, multicentre, multinational, parallel design, phase 2 trial