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NMDA receptors participate in normal synaptic transmission, synaptic development and synaptic plasticity, and are involved in the pathogenesis of some neurological states and diseases including stroke, epilepsy, schizophrenia and neuropathic pain (Cull-Candy et al., 2001 )

More precisely, by manipulating the network architecture, training regimes, and introducing controlled perturbations, it is now possible to probe fundamental questions about visual computation that would be difficult to address in real biological systems