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A systematic review shows that aducanumab reduced brain A plaques in a time- and dose-dependent manner, and aducanumab reduced the severity of clinical dementia in the high-dose treated group (Rahman et al., 2023)

Analytical methods The serum concentrations of the endocannabinoids 2-AG and AEA were measured using a previously established technique ( Liver histology Liver tissue sections (5 m) were stained with H&E, visualized under a bright-field microscope, and analyzed with Image Pro-Plus software to assess steatosis and calculate the NAFLD activity score (NAS) following Vega Joubert et al

This includes management of hepatic and renal failure if they occur and intubation if the patient becomes obtunded