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Thirdly, in the event that the oral bioavailability of CoQ10 cannot be improved, or that CoQ10 cannot cross the bloodbrain barrier in humans, alternative routes of administration (showing promise in experimental models) should be further developed for clinical application

10.7759/cureus.16686 Arjola Agolli, Olsi Agolli, Diana Fiorela Snchez Velazco, Md Ripon Ahammed, Mehrie Patel, Jose Cardona-Guzman, Radhika Garimella, Natcha Rummaneethorn, Seema Bista, Rafael Abreu, Nikole Czapp, Manuel Garcia

Controlled clinical trials indicated that PLC provides enhanced work capacity in persons with congestive heart failure [27] and peripheral vascular disease [28]

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