genes influencing glutathione The Impact of Genetics on Oxidative Stress Influence of glutathione-related genetic variants

Not groundbreaking, but surprisingly easy to ignore when the glow starts to slip

Hermes-Uliana C, Panizzon CPDNB, Trevizan AR, Sehaber CC, Ramalho FV, Martins HA, et al

Decreased D1 expression in the anterior cingulate cortex of ADHD individuals was associated with severe hyperactivity, activated microglia in the dorsolateral prefrontal and the orbitofrontal cortices, and deficits in attentional ability and processing speed (Yokokura et al., 2021)

One notable exception is the observation in significant studies that NAC is highly effective in elevating glutathione under conditions where there has been a dramatic (acute depletion) drop in intracellular glutathione levels, for instance, as is the case in acetaminophen overdose