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Insulin resistance and central obesity are regarded as the primary causes
Of interest is the strict conservation of the four cysteines (Cys14, Cys47, Cys101 and Cys169) that confer peculiar redox sensitivity to this enzyme
10.1080/10739680590960962 [DOI] [PubMed] [Google Scholar] Nikolaev, S
During hypoxia -ketoglutarate may also be converted to citrate, which is used for fatty acid synthesis, amino acids synthesis, or production of the reducing agent NADPH
