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Worse, they impair the very systems your body relies on to get rid of them, making detoxification harder the longer they stick around

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The oxygen is then deprotonated (Step 3, arrows E and F)

This accumulation is mediated by plasmalemmal transporters predominantly expressed in glial cell, such as divalent metal transporter 1 DMT1/SLC11A2 or zinc transporter ZIP14/SLC39A14, 374,375 which both transport Fe 2+ (ferrous), whereas Fe 3+ (ferric) is accumulated through transferrin receptors