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Collectively, these analyses indicate that effective dual PDE1B/PDE10A inhibitors will require finely tuned physicochemical properties, strong metabolic stability, and minimal efflux liability to achieve sustained brain exposure with adequate selectivity

RLM incubation in combination with a NADPH regenerating system and 3A4 Supersomes in the presence of NADPH yielded optimal conditions for APAP in vitro metabolism

Long-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus
