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To further expand the set of SpyLock-based bispecific formats for screening, it should also be possible to combine SpyLock with knob-in-hole Fc domains, with the caveat that exposed disulfides in the hinge region should either be avoided or, alternatively, reoxidized after bispecific generation 40

Comparing MED1 peaks with high versus low acetylation, defined as the top 10% and bottom 10% of peaks according to the results of sequential ChIP-seq, respectively (Extended Data Fig

Localized Treatment : Targeting the problem area directly, ICP minimizes systemic side effects and does not interfere with other ongoing treatments

Ongoing research is needed, but these anecdotes provide hope for those looking to explore nutritional interventions as part of their autoimmune disease management
