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[183] showed that HRS reduces apoptosis induced by skin I/R and improves flap survival modulation of the Bax/Bcl2 ratio and inhibition of the activated Apoptosis SignalRegulating Kinase 1/JNK pathway

Pedroza-Garcia J

in fact, the oxidized form GSSG shows an activating effect on ACE activity, whereas the reduced GSH provides an inhibitory effect [28]