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The pathogenic processes involved are multifactorial, encompassing direct impacts on the host and cooperative interactions with indigenous commensal microbiota that can lead to immune dysregulation

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407 Selecting potential subgroups for chemotherapy de-escalation still needs further validation

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Bowman, S

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Concluding Remarks The multilayered functional interactions of the mTOR signaling pathways and the process of autophagy are deciphered to a great extent at the cellular level, but we still have an incomplete understanding of their integration at the physiopathological level

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