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Topiramate additionally requires precaution in women of childbearing potential as topiramate is associated with oral clefts if used during early pregnancy
KPV offers anti-inflammatory effects without immunosuppression
CD8 + cells recognize the encephalitogenic epitope myelin OL protein 35 50 (MOG 35 50 ) and induce demyelination through the secretion of granzyme B, lymphotoxin, and IFN (Ifergan et al., 2011)
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