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Even more to the point, tumor-associated endothelial cells (TECs) evolve into mesenchymal phenotypic cells by endothelial-mesenchymal transition, which drives various cancerous biological characteristics of tumors, including aberrant angiogenesis, CAF formation, tumor metabolism, invasion, metastasis, and resistance to treatment ( The transformation of ECs into capillaries requires endothelial growth, migration, invasion, and matrix remodeling ( in vitro model and found EGCG might inhibit the tumor vascularization microenvironment of TECs ( In TME, tumor cells typically produce high levels of VEGF, which is essential to support tumor growth and survival

Improvement of vitamin B12 status with Spirulina supplementation in Wistar rats validated through functional and circulatory markers

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