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One study involving 16 patients reported the sensitivity and specificity values of CCM being 44 and 55%, respectively, as compared with skin biopsy [238], whereas another found that the sensitivity and specificity of these three main CCM parameters ranged between 60 and 80% [239]

Aging is a major risk factor for the development of PD and leads to significant alterations in energy metabolism, 337,338 particularly manifested as mitochondrial dysfunction and impairments in the TCA cycle and ETC

Genetic factors Asthma is clearly caused by the combination of environmental factors and genetic factors that significantly contribute to the individual's asthma predisposition [42] and which may influence endotypes of asthma [43]

PUFAs and their mediators regulate brain processes, such as neurotransmission, neurogenesis, neuroinflammation, and neuron protection
