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Understanding these compensatory responses could inform strategies to delay motor signs through early interventions targeting synaptic plasticity and neurotransmitter balance

Peripheral inflammatory signals and energy deficits may impact brain tissue through multiple pathways, activating microglial cells and astrocytes, disrupting neuronal metabolism and synaptic transmission, and thereby potentially contributing to the neurological phenotype of PEM

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As the sector grows, we need platforms and frameworks that prioritize actionable insights, interdisciplinary collaboration, and evidence over volume