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6.3 Dendrimers Dendrimers are organic molecules characterized by their highly branched, tree-like polymeric structure, including well-defined architectures and many functional groups on their surfaces (140)

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58 In contrast, the present study highlights the change of an oxidative stress-associated molecule in the chronic stage of SZ and BP

Compound 22 , a hybrid with the N-terminal from 21 and the C-terminal from 16 demonstrated a further enhanced potency (Ki = 23 nM) and a high selectivity for IRAP over AP-N ( 16 , devoid of a macrocyclic ring system in the N-terminal is not selective and inhibits both IRAP and AP-N activity, suggesting that introduction of proper conformational constrains in the N-terminal by macrocyclization improves selectivity ( 15 and Ang IV seem to adopt a -turn at the C-terminal when binding to IRAP, while in the case of 21 , a less well-defined turn conformation is adopted at the N-terminal