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NAC can also directly react with ROS (H 2 O 2 ), eliminating superoxide anions, hydrogen peroxide, and other ROS [295]

In the GARNET study, 104 patients with EC who had progressed after at least 1 line of chemotherapy were treated with dostarlimab, a PD-1 inhibitor, with an ORR of 42.3%, disease control rate (DCR) of 57.7%, and mPFS of 8.1 months (95% CI 3.018)

In a mouse model of T cell activation, treatment with vitamin C on 2,4-dinitro-1-fluorobenzene (DNFB)-induced delayed-type hypersensitivity response, increased levels of TNF- and IFN- but decreased IL-4 level (Noh et al

FIGURE 2 Artemisinins biological activity is linked to its peroxy bridge, derivatives are created by modifying its structure while retaining the peroxy bridge