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Plasma and erythrocyte ChE activities (measured initially and at intervals of approximately 2 weeks) were normal in the lowest dose group (0.3 mg/kg body weight) but reduced in the other dose groups

Pancreatic cancer Obesity increases risk of pancreatic cancer by about 20%.8 Diabetes is also associated with increased risk, and a mendelian randomisation analysis indicates that this is due to raised insulin rather than diabetes itself.59 Studies of dietary components and risk have been inconclusive.8 Lung cancer Lung cancer is the most common cancer in the world, and heavy smoking increases risk around 40-fold.67 Prospective studies have indicated that diets higher in fruits and vegetables are associated with a slightly lower risk of lung cancer in smokers, but not in never smokers.6061 The weak inverse association of fruit and vegetables with lung cancer risk in smokers might perhaps indicate some true protective effect, but it might simply be due to residual confounding by smoking (box 1)

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