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Mutant glucocerebrosidase impairs -synuclein degradation by blockade of chaperone-mediated autophagy

A significant dose-response relationship between ibuprofen intake (tablets/week) and reduced PD risk was found

3.6 Integrated transcriptomicproteomic analysis 3.6.1 Overview of differential expression at transcriptomic and proteomic levels Among 17,251 genes analyzed, 116 DEGs (0.67%) were identified, comprising 41 up-regulated and 75 down-regulated genes