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Acute intranasal oxytocin improved social behavior in Oprm1- KO mice within 5 min after administration [42]
doi: 10.1006/bbrc.2001.6179 81 GhoshSPreetAGroopmanJEGanjuRK

Transcytosis is a mechanism through which IgA can cross the IEB and arrives into the lumen

However, you can manage its flare ups and severity through lifestyle changes and medicines