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Hearts from heterozygous (GPx1 +/ ) knockout mice were more susceptible to diastolic dysfunction following ischemia/reperfusion (I/R) injury than wildtype hearts [39] and GPx1 / hearts (from male mice) showed both contractile and diastolic dysfunction following I/R, with an increase in oxidative stress as measured by an increase in protein carbonylation [40]

17 (1_suppl): S23S29

10.1097/CCM.0000000000004625 [DOI] [PMC free article] [PubMed] [Google Scholar] 254.Ghati A, Dam P, Tasdemir D, Kati A, Sellami H, Sezgin GC, et al

Adv Pharmacol 38:20527, PMID: 8895810 Jain A, Mrtensson J, Stole E, Auld PA, Meister A (1991) Glutathione deficiency leads to mitochondrial damage in brain