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Description
This mechanism is supported by preclinical work but has not been confirmed in large human trials
amylin signals through the area postrema and is thought to restore leptin sensitivity, an effect that may help counter the bodys defense of a higher fat-mass set point
Biological plausibility and experimental findings are not the same thing as proven clinical benefit
We saw a difference in the gene expression profile at a certain time point and suppose that the higher level of transcription is accompanied by greater protein synthesis
