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For example, activation of autophagy can lead to cardiac disease, atherosclerosis, block interneuron progenitor cell growth, foster neuronal death, lead to memory impairment, and prevent neurovascular protection with growth factors

Analysis of 14 paired liver biopsies revealed significantly lower baseline peripheral mtDNA copy number in NASH versus simple steatosis patients, establishing an association between mitochondrial dysfunction and disease severity

5A, the crude protein level in the carnitine supplementation group was significantly increased compared with the control group in the feeding state, but was significantly decreased in the fasting state (Fig