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Moreover, APOE promotes tumor growth and proliferation in PTC through glycolysis, and analysis has shown that the FTO/APOE axis inhibits PTC glycolysis by modulating the IL-6/JAK2/STAT3 signaling pathway [86]

MDM2 mediates the ubiquitin-dependent degradation of SPY1, resulting in a downregulation of SPY1 expression, which in turn upregulates the expression of ALOX15 and growth differentiation factor 15 (GDF15), while decreasing the levels of GCH1, GPX4, and GSH

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Kovalovich K, Li W, DeAngelis R, Greenbaum LE, Ciliberto G, Taub R