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In particular, we have developed and tested preclinical compounds, such as INF-4E, INF195, and INF200, which reduce NLRP3 activation, improve post-ischemic cardiac function, and decrease infarct size [59, 60, 145]

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The authors remind us that in past parabiosis experiments (where blood is exchanged between old and young mice), the brain tissue of the young mice grew older but brains of the old mice didnt get younger

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