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This chapter will not include detailed descriptions of the effects of LT4 on the heart or the skeleton: these aspects are covered in chapters, Levothyroxine and the Heart and Levothyroxine and Bone of this book, respectively

Keywords: growth hormone, paediatrics, short stature, insulin-like growth factor-I, insulin-like growth factor, binding protein-3 Introduction The growth hormone (GH)insulin-like growth factor (IGF)-I axis is the principle endocrine system regulating linear growth in children (1)

Figure 5 Downstream cellular mediators of Dihexa protection Activation of the receptor tyrosine kinase c-Met leads to the recruitment of many signaling mediators and ultimately the activation of downstream signals, most notably Akt-TOR and Ras-ERK (Organ and Tsao, 2011)