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(47) revealed the harmful effects of chronic alcohol consumption on bones in that long-term intake of large amounts of ethanol affects the gut microbiota while stimulating the negative regulation of the gutbone axis by 5-HT, which in turn induces the genesis of alcoholic osteoporosis in rats

Banimohamad-Shotorbani B, Karkan SF, Rahbarghazi R, Mehdipour A, Jarolmasjed S, Saghati S, et al

So, what if you could buffer this decrease in glutathione with dietary supplementation and nutrient timing

For instance, in vitro co-cultures and synthetic gut microbiome communities have shown that riboflavin promotes cross-feeding networks involving butyrate production pathways 207,208