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In SCD, abnormal haemoglobin causes red blood cells to stiffen into a characteristic sickle shape under low-oxygen conditions

These parameters can be used to generate synthetic time domain data for each signal, and this synthetic data can be Fourier processed in the same way as the measured data to create model spectra (Fig

Jing et al

The direct assessment of MDA and 4-HNE is not very sensitive, since the major portion of these reactive aldehydes is attached to proteins or other biomolecules and therefore before analysis, should be released, otherwise, they remain undetected (Esterbauer et al
