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Epigenetic modifications, such as mtDNA hypermethylation, impair mitochondrial gene expression and respiration, while decreased SIRT3 activity contributes to the loss of redox homeostasis in retinal endothelial cells (18)

doi: 10.2337/db09-0801

Tripathy J, Tripathy A, Thangaraju M, Suar M, Elangovan S (2018) -Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGF signaling

Over time, it has expanded into functional and integrative medicine as part of comprehensive detoxification protocols
