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The establishment of 1919 GBM cells with overexpression of wildtype PSPH and PSPH V116I was confirmed by enhanced expression of PSPH by immunoblot and consecutive upregulation of ser/gly pathway enzyme SHMT2, most pronounced in PSPH V116I cells (Fig
Fujita K, Nozaki Y, Wada K, Yoneda M, Fujimoto Y, Fujitake M, Endo H, Takahashi H, Inamori M, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A (2009) Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis

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Side effects at 2.4mg (48 units) The full maintenance dose produces the highest incidence of side effects
