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The establishment of 1919 GBM cells with overexpression of wildtype PSPH and PSPH V116I was confirmed by enhanced expression of PSPH by immunoblot and consecutive upregulation of ser/gly pathway enzyme SHMT2, most pronounced in PSPH V116I cells (Fig

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Fujita K, Nozaki Y, Wada K, Yoneda M, Fujimoto Y, Fujitake M, Endo H, Takahashi H, Inamori M, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A (2009) Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis

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Side effects at 2.4mg (48 units) The full maintenance dose produces the highest incidence of side effects

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