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doi: 10.1021/bi991028u
Lewy bodies, primarily composed of misfolded synuclein, aggregate within neurons, disrupting cellular proteostasis and damaging mitochondria, thus promoting neuronal toxicity (Figure 2) [5]
Indeed, downregulation of CAT protein expression was reported in MASH patients as compared to control (Shearn et al
These results confirm that VacA disrupts TRPML1 activity and causes disruption of lysosomal calcium homeostasis
