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Small molecule derivatives of 4-amino-quinoline, in particular, are non-covalent and demonstrate an IC50 values in the nanomolar range (103, 104) and include three lead compounds: 78c (IC50 7.3 nM), 1ai (IC50 46 nM), and Iah (IC50 115 nM)

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Permanent hair reduction is defined as the long-term, stable reduction in the number of hairs re-growing when measured at 6, 9, and 12 months after the completion of a treatment regime, as well as treatment of benign pigmented lesions (sun spots and brown spots), wrinkles, and vascular lesions (such as port-wine stains, hemangiomas, telangiectasias)
