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Taking advantage of the clinical features dataset, Van der Ham K et al
perfringens produces irregular colonies with an inner narrow zone of complete hemolysis (due to theta toxin), surrounded by a much wider zone of incomplete hemolysis (due to the alpha-toxin)
Investigational agents involving the ISR in current ALS clinical trials target the eIF2 complex, PP1R15A, and pathological RAN translation (Table 3)
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