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Also, with the current high level of concern about possible skin damage from sun exposure, many people cover up or use so much sunscreen that the sun cannot access their skin to make vitamin D3

However, the advantage of scavengers over enzymatic antioxidants is their small size, which allows them to diffuse through cell membranes and localize near biological molecules which are potential targets of ROS (Kohen and Nyska, 2002)

Aside from its role in catecholamine catabolism, COMT converts an antiestrogen compound (2-hydroxyestradiol) to a proestrogen (2-methoxyestradiol) and leads to an estrogen-rich environment

doi:10.1016/j.cnp.2019.01.005 Venhovens J, Meulstee J, Verhagen WIM