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10.1080/17461391.2014.959564 Eur J Sport Sci
Reactive Oxygen Species (ROS) are increased by the consumption of sugars and oxidized vegetable oils, smoking, alcohol, exposure to environmental toxins, high or chronic emotional stress, circadian rhythm dysregulation (poor sleep), lack of exercise, infections, and a lack of antioxidant intake

The expression of this component of the ECM is, however, found to be reactivated under pathological angiogenesis
