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In this classic signaling pathway, ligand-activated ER dissociates from its chaperone heat-shock protein and binds as a dimer either directly to an estrogen response element (ERE) in target gene promoters or indirectly to activator protein 1 or specificity protein 1 response elements through protein tethering to DNA (13)

The pools of sulfate ions are limited in the body

Moretti A, Fonteyne L, Giesert F et al (2020) Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

Similarly, a study assessing the impact of early exposure to prenatal T in sheep between gestational days 2065 did not note any difference in weight trajectory in testes intact and orchiectomized twins 40