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PLoS Genet 7:e1002046 Segonzac C, Zipfel C (2011) Activation of plant pattern-recognition receptors by bacteria

[ 2,3] Deficits in cholinergic function are a major feature of age-related declines in memory, with loss of cholinergic neurons (i.e., the nerve cells that make and release acetylcholine) and decreased ability to make acetylcholine contributing to the poorer memory and attention

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These products often face fragmented oversight, as their classification can trigger separate drug, biologics and device review requirements, increasing development time and cost