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486 Overexpression of GPX4 in cardiomyocytes or targeting the mitochondrial DOX-Fe 2+ complex prevents DOX-induced ferroptosis and improves cardiomyocyte injury
H 2 S can react with oxidized thiol (sulfenic acid) compounds, including protein thiols, to yield persulfides, which have higher nucleophilicity than the corresponding monosulfides 31
Patient expectations also create barriers to diagnostic approach changes
Ongoing Monitoring and Dose Adjustments After the initial 12-week phase, monitoring shifts to every 8 to 12 weeks for the next 6 months, then annually once you stabilize
