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This is because certain formulations can affect each other and thereby reduce their respective benefits

Our study observed a similar trend in directional change, but the effect sizes for individual metabolites were not large enough to reach statistical significance (see Fig

In agreement with this, Horton et al

It was proposed that chelating agents like EDTA, N -hydroxyethylethylenediamine- NN'N' -triacetic acid (Walsh et al., 2003) and to a lesser extent nitrilotriacetic acid (Haque and Russell, 1974) serve as a potentiating agent, as they destabilize the outer membrane and create easier access for other compounds
