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While recent studies have attempted whole genome sequencing of endangered species for conservation purposes (vonHoldt et al., 2016

doi: 10.1177/1947603519880321 180 EvansCHGhivizzaniSCRobbinsPD

10.1186/s12935-018-0524-0 10.1186/s12935-018-0524-0 [DOI] [PMC free article] [PubMed] [Google Scholar] Goldstein BD, Lodi C, Collinson C, Balchum OJ (1969) Ozone and lipid peroxidation

This includes proposed up-regulation of endothelial nitric oxide synthase (NOS3), decreased stimulation of endothelial cells, development of anti-oxidative responses, decreased migration of inflammatory cells, decreased antigen presentation because of suppressed MHC II expression in endothelial cells [57] resulting from promoter IV of class II trans-activator (CIITA) [58], down-regulation of pro-inflammatory cytokines, decreased PLT accumulation, development of 15-epi-lipoxin (15-epi-LXB4), which operates through preventing the signaling pathways engaged in the stimulation of the inflammatory response induced by lipid agents [59, 60] and, finally, enhanced migration, differentiation, and prohibitory functions of Treg cells [59, 61]