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B12 is typically absorbed through the stomach, so if you havestomach issues or have taken many common medications you may not be able to absorb it as effectively

doi: 10.1074/jbc.M111053200 20 LambertAJBuckinghamJABoysenHMBrandMD

The rationale is that fasting naturally promotes lipolysis through reduced insulin and increased catecholamine activity, and the peptide may synergize with this state to maximize fat breakdown