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In comparison, the mRNA level for GPX4 was markedly reduced (by approximately 70%) in APAP-treated animals, which is in agreement with an earlier study [12], and joint treatment of the animals with cystamine abrogated the reduction in liver GPX4 mRNA level (Fig

In both endogenous and exogenous LC3 assessment, chloroquine considerably increases LC3/GFP-LC3 puncta (Figures 2B, 3B)

These nefarious molecular structures are unstable, and cause oxidative damage to cells which can set the stage for accelerated aging, and life-threatening diseases

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