Frontiers
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Description
Once TMA is produced, it is absorbed into the bloodstream and transported to the liver, where the enzyme flavin-containing monooxygenase (FMO) oxidizes TMA into trimethylamine-N-oxide (TMAO)
In contrast, CT2 downregulation results in resistance to CDDP by decreasing intracellular platinum concentration [74]
10.1016/j.exger.2007.05.004 91 LiX.ChauhanA.SheikhA
Higher levels of ROS within myofibers trigger pathophysiological signaling and induce apoptosis and proteolysis [137, 138]
