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This action inhibits ferroptosis in H9C2 cells in vitro and alleviates SIC in vivo in a dose-dependent manner, suggesting a potential treatment strategy for SIC (Wang et al., 2023a

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By contrast, in pattern recognition receptor-mediated bypass, toll-like receptor 3 directly recruits RIPK3 via the TIR domain-containing adapter molecule 1 (TRIF), forming a nonclassical necrosome complex that bypasses RIPK1

Ragusa et al
