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Contraindications include those who are pregnant, have skin infections near the treatment area, or have serious health problems

[2] While its toxic effects can be damaging, the sensing of lipid A by the immune system may also be critical for the onset of immune responses to gram-negative infection, and for the subsequent successful fight against the infection

A later study on the human hepatocyte cell culture demonstrated that other APs like haloperidol, olanzapine, and risperidone activated SREBP and increased expression of target genes involved in FFAs biosynthesis, resulting in intracellular lipids accumulation (Lauressergues et al

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