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Methods Sequence retrieval and alignment To reconstruct gene diversification of components of plastid and mitochondrial redox cascades, protein sequences were retrieved from OrcAE for Chara braunii ( Phytozome v12.1 [125] for Chlamydomonas reinhardtii , Marchantia polymorpha , Physcomitrium ( Physcomitrella) patens, Selaginella moellendorffii and Brachypodium distachyon , Fernbase ( for Salvinia cucullata and Azolla filiculoides , and TAIR10 (www.arabidopsis.org) for Arabidopsis thaliana

The glucose lowering benefits of mulberry is most likely due, in part, to the presence of quercetin as this antioxidant polyphenol has been shown is several animal and human studies to reduce blood glucose levels

doi: 10.1002/ddr.21515 57

These changes are driven by multiple thermosensory transcription factors (TTFs), which accumulate and/or activate as temperature rises and regulate genes involved in phytohormone signaling and cell-wall modifications 5,6