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In an MCAO/R model using ICR mice, prophylactic administration of PACs via gavage at a minimum dose of 25 mg/kg daily for 7 days enhanced neurological function, reduced infarct volume, and activated the Nrf2/HO-1 signaling pathway
Dermal MSCs inhibit the proliferation of skin-homing CTLs and induce their apoptosis, and can be used as an adjuvant to autologous MCs transplantation to improve efficacy [150]
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That said, there are some potential side effects that can come with astaxanthin when taken in extremely high doses (50mg or more)
