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At least 5% of ASD cases are caused by single nucleotide polymorphisms (SNPs) in genes such as NLGN3, NLGN4, NRXN1, MECP2, SHANK3, FMR1, and UBE3A, with about 10% of these variants being copy number variations (CNVs) that disrupt protein-coding sequences (6163)

However, hydra-zine bonds can undergo hydrolysis in plasma causing the unintended release of drug molecules leading to systemic toxicity 116

Two studies directly tested this hypothesis with one negative trial showing no vasodilation (Lauer et al ., 2001) and a second positive study showing significant forearm circulation vasodilation at both pharmacological and slightly supraphysiological concentrations (Cosby et al ., 2003)