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Tamoxifen is a selective oestrogen receptor modulator (SERM) widely prescribed in the UK for hormone receptor-positive breast cancer, both as an adjuvant treatment following surgery and, in accordance with NICE guideline CG164 (Familial breast cancer), as a risk-reduction option in high-risk individuals
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It also plays a role in detox and muscle support
High homocysteine levels can cause endothelial dysfunction, which then can lead to oxidative stress and inflammation, both of which can result in white matter changes
