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Similarly, SPR994, a prodrug known as Terbipenem, is a carbapenem hydrobromide salt esterified with a pivoxil promoiety

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This preventive effect was abrogated in PPAR-alpha knockout mice, or when animals received a PPAR-alpha antagonist, suggesting that the effects of fenofibrate against DR are PPAR-alpha mediated [30]

doi: 10.1016/0092-8674(93)90529-y 17 BushatiNCohenSM